The Sheikh Zayed Institute for Pediatric Surgical Innovation at Children’s National Health System in Washington, DC, is pursuing the goal of making pediatric surgery more precise, less invasive, and pain free. By combining research and clinical work in the areas of imaging, bioengineering, pain medicine, immunology and personalized medicine, the Institute’s physicians and scientists are developing knowledge, tools, and procedures that will benefit children globally. The Institute also offers multiple funding opportunities to pediatric device innovators annually, both independently and as an FDA-funded Pediatric Device Innovation Consortium, and helps them pave the road to market/bedside by forging relationships with its network of prospective investors as well as experts in business, regulatory, engineering, and clinical fields. The Institute was founded in 2010 thanks to a historic and transformational gift of $150 million from the government of Abu Dhabi – the largest gift ever made to any children’s hospital.